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The Arquette Siblings
David Arquette
David Arquette
Charlie Weaver
Charlie Weaver
Patricia Arquette
Patricia Arquette
Rosanna Arquette, best known for playing straight woman to Madonna in Desperately Seeking Susan, is the niece of Charlie Weaver, a comic character actor best known as a regular on the original Hollywood Squares game show. So is her sister, Patricia Arquette (star of Stigmata and TV's Medium), who is married to Thomas Jane (The Punisher, The Mist). And then there's their brother, David Arquette, star of Scream and and the husband of Courtney Cox. Lesser known are the other two siblings: Actor Richmond Arquette most recently played "Deputy Charles" in Rob Zombie's remake of Halloween (2007). Robert Arquette made his debut as the young boy on a carnival ride in the 1982 music video "She's a Beauty" by The Tubes. He later underwent a sex change operation and is now Alexis Arquette. He/she has made more than 60 television and film appearances, including a memorable turn as a Boy George fanatic singing "Do You Really Want to Hurt Me" in Adam Sandler's The Wedding Singer. Rosanna, incidentally, was the inspiration for and appeared in the video of the song "Rosanna" by Toto.

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