Cheers and Frasier actor/producer Kelsey Grammer is the father of actress Spencer Grammer, who starred on ABC Family's hit show Greek from 2007-2011. Her mother, Kelsey's first wife, is dance instructor/actress Doreen Alderman (1988's Death Flash and 1990's Body Chemistry). Spencer also appeared on As the World Turns, Law & Order: SVU, and Third Watch. Her first onscreen appearance was on a 1992 episode of Cheers as uncredited "Little girl."
Spencer's younger half-sister, Greer Grammer (TV's Awkward), appeared in 2010's Almost Kings and on an episode of iCarly the same year. Greer is also a beauty queen, having held the titles of Miss Teen Malibu 2008 and 2009, as well as Miss Regional California Teen USA 2011. She competed in Miss California Teen USA 2008-2010, placing in the Top 10 each of those three years. Greer's mother is makeup artist/hairstylist Barrie Buckner, who has worked on films such as Spaced Invaders (1990), Critters 3 (1991), Deep Cover (1992), Critters 4 (1992), and The Thundering 8th (2000).
Kelsey's third ex-wife Camille Grammer (1996's The Naked Detective), a onetime MTV dancer and Playboy model, starred on two seasons of Bravo's The Real Housewives of Beverly Hills from 2010-2012. The demise of her marriage to Kelsey was part of Camille's storyline on the reality show. Kelsey appeared on two episodes. Camille appeared on an episode of Frasier in 1997. She also appeared in three episodes of Kelsey's show Gary the Rat in 2003. Camille and Kelsey co-wrote/created the 2001 TV movie Neurotic Tendencies, which Kelsey also directed.
On July 13, 2012, Kelsey and his fourth wife Kayte welcomed a daughter, Faith Evangeline Elisa Grammer. However, they also announced that a son, who was to be born a twin to their daughter, had been tragically lost earlier during the pregnancy.