Actress Drew Barrymore (E.T., Scream, The Wedding Singer) is the daughter of actor John Drew Barrymore (who appeared in about two dozen mostly-B movies in the 1950s and 1960s) and actress Jaid Barrymore (who has appeared in about two dozen mostly-B movies since the early 1980s). Drew is the granddaughter of legendary actor John Barrymore and the grand-niece of Ethel Barrymore and Lionel Barrymore. The three siblings only appeared in one film together, 1932's Rasputin and the Empress. After John's death, Lionel and Ethel appeared together in 1953's Main Street to Broadway. Actor/director Sidney Drew, who had 168 roles from 1908-1919, was an uncle to the three actors. Dolores Costello Barrymore, Drew's grandmother, was known in the early 1900s as the "goddess of the silent screen." Her sister, Helene Costello, was an actress as well. Their parents Mae Costello and Maurice Costello were both actors in the early 1900s. In fact, Dolores and Helene both appeared in a number of their father's films, beginning with 1909's A Midsummer Night's Dream.
Drew Barrymore made headlines when she entered rehab at the age of 13. Reportedly, this resulted from her mother Jaid's tendency to take Drew with her when she partied as places such as the legendary Studio 54. As a result, Drew began drinking and doing drugs by the time she was 10, and she attempted suicide at 14. Determined to break the Barrymore curse of addiction, she got sober and, at the age of 15, sued for emancipation from her parents. She even took a job in an LA coffee shop until she was slowly able to work her way back into acting. Clearly nepotism can be both a blessing and a curse.